The mGluR5 negative allosteric modulator dipraglurant reduces dyskinesia in the MPTP macaque model.
Identifieur interne : 000390 ( Main/Exploration ); précédent : 000389; suivant : 000391The mGluR5 negative allosteric modulator dipraglurant reduces dyskinesia in the MPTP macaque model.
Auteurs : Erwan Bezard [République populaire de Chine] ; Elsa Y. Pioli ; Qin Li ; Françoise Girard ; Vincent Mutel ; Charlotte Keywood ; Francois Tison ; Olivier Rascol ; Sonia M. PoliSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- Analysis of Variance, Animals, Antiparkinson Agents (adverse effects), Disease Models, Animal, Dose-Response Relationship, Drug, Dyskinesia, Drug-Induced (blood), Dyskinesia, Drug-Induced (drug therapy), Excitatory Amino Acid Antagonists (blood), Excitatory Amino Acid Antagonists (chemistry), Excitatory Amino Acid Antagonists (therapeutic use), Imidazoles (pharmacology), Imidazoles (therapeutic use), Levodopa (adverse effects), MPTP Poisoning (drug therapy), Macaca mulatta, Male, Motor Activity (drug effects), Pyridines (pharmacology), Pyridines (therapeutic use), Receptor, Metabotropic Glutamate 5 (metabolism), Severity of Illness Index, Time Factors.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- blood : Dyskinesia, Drug-Induced, Excitatory Amino Acid Antagonists.
- chemical , chemistry : Excitatory Amino Acid Antagonists.
- drug effects : Motor Activity.
- drug therapy : Dyskinesia, Drug-Induced, MPTP Poisoning.
- chemical , metabolism : Receptor, Metabotropic Glutamate 5.
- chemical , pharmacology : Imidazoles, Pyridines.
- chemical , therapeutic use : Excitatory Amino Acid Antagonists, Imidazoles, Pyridines.
- Analysis of Variance, Animals, Disease Models, Animal, Dose-Response Relationship, Drug, Macaca mulatta, Male, Severity of Illness Index, Time Factors.
Abstract
Blocking metabotropic glutamate receptor type 5 (mGluR5) has been proposed as a target for levodopa-induced dyskinesias (LID) in Parkinson's disease (PD). We assessed the effect on LID of dipraglurant, a potent selective mGluR5 receptor negative allosteric modulator in the gold-standard LID macaque model.
DOI: 10.1002/mds.25920
PubMed: 24865335
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000491
- to stream PubMed, to step Curation: 000491
- to stream PubMed, to step Checkpoint: 000394
- to stream Ncbi, to step Merge: 004008
- to stream Ncbi, to step Curation: 004008
- to stream Ncbi, to step Checkpoint: 004008
- to stream Main, to step Merge: 000390
- to stream Main, to step Curation: 000390
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The mGluR5 negative allosteric modulator dipraglurant reduces dyskinesia in the MPTP macaque model.</title><author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name><affiliation wicri:level="4"><nlm:affiliation>Motac neuroscience, Manchester, UK; Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France; Service de Neurologie, CHU de Bordeaux, Pessac, France; Institute of Laboratory Animal Sciences, China Academy of Medical Sciences, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Motac neuroscience, Manchester, UK; Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France; Service de Neurologie, CHU de Bordeaux, Pessac, France; Institute of Laboratory Animal Sciences, China Academy of Medical Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Bordeaux</orgName></affiliation></author><author><name sortKey="Pioli, Elsa Y" sort="Pioli, Elsa Y" uniqKey="Pioli E" first="Elsa Y" last="Pioli">Elsa Y. Pioli</name></author><author><name sortKey="Li, Qin" sort="Li, Qin" uniqKey="Li Q" first="Qin" last="Li">Qin Li</name></author><author><name sortKey="Girard, Francoise" sort="Girard, Francoise" uniqKey="Girard F" first="Françoise" last="Girard">Françoise Girard</name></author><author><name sortKey="Mutel, Vincent" sort="Mutel, Vincent" uniqKey="Mutel V" first="Vincent" last="Mutel">Vincent Mutel</name></author><author><name sortKey="Keywood, Charlotte" sort="Keywood, Charlotte" uniqKey="Keywood C" first="Charlotte" last="Keywood">Charlotte Keywood</name></author><author><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="Francois" last="Tison">Francois Tison</name></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name></author><author><name sortKey="Poli, Sonia M" sort="Poli, Sonia M" uniqKey="Poli S" first="Sonia M" last="Poli">Sonia M. Poli</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24865335</idno><idno type="pmid">24865335</idno><idno type="doi">10.1002/mds.25920</idno><idno type="wicri:Area/PubMed/Corpus">000491</idno><idno type="wicri:Area/PubMed/Curation">000491</idno><idno type="wicri:Area/PubMed/Checkpoint">000394</idno><idno type="wicri:Area/Ncbi/Merge">004008</idno><idno type="wicri:Area/Ncbi/Curation">004008</idno><idno type="wicri:Area/Ncbi/Checkpoint">004008</idno><idno type="wicri:Area/Main/Merge">000390</idno><idno type="wicri:Area/Main/Curation">000390</idno><idno type="wicri:Area/Main/Exploration">000390</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The mGluR5 negative allosteric modulator dipraglurant reduces dyskinesia in the MPTP macaque model.</title><author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name><affiliation wicri:level="4"><nlm:affiliation>Motac neuroscience, Manchester, UK; Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France; Service de Neurologie, CHU de Bordeaux, Pessac, France; Institute of Laboratory Animal Sciences, China Academy of Medical Sciences, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Motac neuroscience, Manchester, UK; Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France; Service de Neurologie, CHU de Bordeaux, Pessac, France; Institute of Laboratory Animal Sciences, China Academy of Medical Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Bordeaux</orgName></affiliation></author><author><name sortKey="Pioli, Elsa Y" sort="Pioli, Elsa Y" uniqKey="Pioli E" first="Elsa Y" last="Pioli">Elsa Y. Pioli</name></author><author><name sortKey="Li, Qin" sort="Li, Qin" uniqKey="Li Q" first="Qin" last="Li">Qin Li</name></author><author><name sortKey="Girard, Francoise" sort="Girard, Francoise" uniqKey="Girard F" first="Françoise" last="Girard">Françoise Girard</name></author><author><name sortKey="Mutel, Vincent" sort="Mutel, Vincent" uniqKey="Mutel V" first="Vincent" last="Mutel">Vincent Mutel</name></author><author><name sortKey="Keywood, Charlotte" sort="Keywood, Charlotte" uniqKey="Keywood C" first="Charlotte" last="Keywood">Charlotte Keywood</name></author><author><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="Francois" last="Tison">Francois Tison</name></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name></author><author><name sortKey="Poli, Sonia M" sort="Poli, Sonia M" uniqKey="Poli S" first="Sonia M" last="Poli">Sonia M. Poli</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Antiparkinson Agents (adverse effects)</term><term>Disease Models, Animal</term><term>Dose-Response Relationship, Drug</term><term>Dyskinesia, Drug-Induced (blood)</term><term>Dyskinesia, Drug-Induced (drug therapy)</term><term>Excitatory Amino Acid Antagonists (blood)</term><term>Excitatory Amino Acid Antagonists (chemistry)</term><term>Excitatory Amino Acid Antagonists (therapeutic use)</term><term>Imidazoles (pharmacology)</term><term>Imidazoles (therapeutic use)</term><term>Levodopa (adverse effects)</term><term>MPTP Poisoning (drug therapy)</term><term>Macaca mulatta</term><term>Male</term><term>Motor Activity (drug effects)</term><term>Pyridines (pharmacology)</term><term>Pyridines (therapeutic use)</term><term>Receptor, Metabotropic Glutamate 5 (metabolism)</term><term>Severity of Illness Index</term><term>Time Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Excitatory Amino Acid Antagonists</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Excitatory Amino Acid Antagonists</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Motor Activity</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>MPTP Poisoning</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptor, Metabotropic Glutamate 5</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Imidazoles</term><term>Pyridines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Excitatory Amino Acid Antagonists</term><term>Imidazoles</term><term>Pyridines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Disease Models, Animal</term><term>Dose-Response Relationship, Drug</term><term>Macaca mulatta</term><term>Male</term><term>Severity of Illness Index</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Blocking metabotropic glutamate receptor type 5 (mGluR5) has been proposed as a target for levodopa-induced dyskinesias (LID) in Parkinson's disease (PD). We assessed the effect on LID of dipraglurant, a potent selective mGluR5 receptor negative allosteric modulator in the gold-standard LID macaque model.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement><orgName><li>Université de Bordeaux</li></orgName></list><tree><noCountry><name sortKey="Girard, Francoise" sort="Girard, Francoise" uniqKey="Girard F" first="Françoise" last="Girard">Françoise Girard</name><name sortKey="Keywood, Charlotte" sort="Keywood, Charlotte" uniqKey="Keywood C" first="Charlotte" last="Keywood">Charlotte Keywood</name><name sortKey="Li, Qin" sort="Li, Qin" uniqKey="Li Q" first="Qin" last="Li">Qin Li</name><name sortKey="Mutel, Vincent" sort="Mutel, Vincent" uniqKey="Mutel V" first="Vincent" last="Mutel">Vincent Mutel</name><name sortKey="Pioli, Elsa Y" sort="Pioli, Elsa Y" uniqKey="Pioli E" first="Elsa Y" last="Pioli">Elsa Y. Pioli</name><name sortKey="Poli, Sonia M" sort="Poli, Sonia M" uniqKey="Poli S" first="Sonia M" last="Poli">Sonia M. Poli</name><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="Francois" last="Tison">Francois Tison</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000390 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000390 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:24865335
|texte= The mGluR5 negative allosteric modulator dipraglurant reduces dyskinesia in the MPTP macaque model.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24865335" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |